Programmed constitutive heterochromatin silencing is essential for eukaryotic genome
regulation, yet the initial step of this process is ambiguous. A large proportion of R-loops …

Parallel research on multiple model organisms shows that while some principles of telomere
biology are conserved among all eukaryotic kingdoms, we also find some deviations that …

Cytosine (DNA) methylation plays important roles in silencing transposable elements, plant
development, genomic imprinting, stress responses, and maintenance of genome stability …

I-motifs (iMs) are non-canonical DNA secondary structures that fold from cytosine (C)-rich
genomic DNA regions termed putative i-motif forming sequences (PiMFSs). The structure of …

Genomic architecture facilitates chromosome recognition, pairing, and recombination.
Telomeres and subtelomeres play an important role at the beginning of meiosis in specific …

The centromere is a chromosomal region where the kinetochore is formed, which is the
attachment point of spindle fibers. Thus, it is responsible for the correct chromosome …

Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent
to each other on eukaryotic chromosomes. Although their primary roles are different, they …

Background The i-motif is a tetrameric DNA structure based on the formation of
hemiprotonated cytosine-cytosine (C+. C) base pairs. i-motifs are widely used in …

Epigenetic mechanisms are involved in regulation of crucial cellular processes in eukaryotic
organisms. Data on the epigenetic features of plant telomeres and their epigenetic …

Key message Prolonged hypomethylation of DNA leads to telomere truncation correlated
with increased telomere recombination, transposon mobilization and stem cell death …