Glycosylation is a widespread glycosyl modification that regulates gene expression and
metabolite bioactivity in all life processes of plants. Phosphoribosylation is a special glycosyl …

Anthranilate phosphoribosyltransferase catalyses the second reaction in the biosynthesis of
tryptophan from chorismate in microorganisms and plants. The enzyme is homodimeric with …

The first step of histidine biosynthesis in Acinetobacter baumannii, the condensation of ATP
and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N 1-(5-phospho-β-d-ribosyl)-ATP …

Verticillium wilt, caused by the ascomycete fungus Verticillium dahliae (Vd), is a devastating
disease of numerous plant species. However, the pathogenicity/virulence-related genes in …

Heavy-isotope substitution into enzymes slows down bond vibrations and may alter
transition-state barrier crossing probability if this is coupled to fast protein motions. ATP …

ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis in
bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate …

Short-form ATP phosphoribosyltransferase (ATPPRT) is a hetero-octameric allosteric
enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) …

Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling
biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the …

ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis,
being allosterically inhibited by the final product of the pathway. Allosteric inhibition of long …

α-Isopropylmalate synthase (IPMS) catalyzes the first step in leucine (Leu) biosynthesis and
is allosterically regulated by the pathway end product, Leu. IPMS is a dimeric enzyme with …