Skeletal muscle, the largest organ in the human body, plays a crucial role in supporting and
defending the body and is essential for movement. It also participates in regulating the …

Background Loss of muscle mass is linked with impaired quality of life and an increased risk
of morbidity and premature mortality. Iron is essential for cellular processes such as energy …

Sarcopenia and obese sarcopenia are increasingly prevalent chronic diseases with
multifactorial pathogenesis, and no approved therapeutic drug to date. In the established …

Identification of new mechanisms mediating insulin sensitivity is important to allow validation
of corresponding therapeutic targets. In this study, we first used a cellular model of skeletal …

Background Previous data in humans suggest that extreme physical inactivity (EPI) affects
iron metabolism differently between sexes. Our objective was to deepen the underlying …

Disruption of iron homeostasis is associated with multiple diseases. It has been found that
patients with genetic iron overload develop massive iron deposition in the pancreas …

Iron is an essential nutrient for all living organisms. Both iron deficiency and excess can be
harmful. Bone, a highly metabolic active organ, is particularly sensitive to fluctuations in iron …

Ferroptosis adversely affects the viability, differentiation, and metabolic integrity of C2C12
myoblasts, contributing to the decline in skeletal muscle health. The intricate mechanisms …

Microgravity exposure can impact various physiological systems, yet its specific effects on
liver cells remain inadequately studied. To address this gap, we used a hindlimb unloading …

Although metabolic complications are common in thalassemia patients, there is still an
unmet need to better understand underlying mechanisms. We used unbiased global …