Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …

The cellular complexity and functional diversity of the human immune system necessitate the
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as …

Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker
discovery in cancer and other diseases. However, flow cytometry is limited by the number of …

Immune checkpoint (IC) therapy provides substantial benefits to cancer patients but can also
cause distinctive toxicities termed immune-related adverse events (irAEs). Biomarkers to …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

High-dimensional single-cell analyses have improved the ability to resolve complex
mixtures of cells from human disease samples; however, identifying disease-associated cell …

How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated
invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear …

Inflammatory monocytes are key mediators of acute and chronic inflammation; yet, their
functional diversity remains obscure. Single-cell transcriptome analyses of human …

Objective The aim of this study was to assess the therapeutic effects of biological DMARDs
(bDMARDs) on the diversity of immune cell phenotypes in peripheral blood of patients with …