Computational cardiac physiology for new modelers: Origins, foundations, and future
Mathematical models of the cardiovascular system have come a long way since they were
first introduced in the early 19th century. Driven by a rapid development of experimental …
first introduced in the early 19th century. Driven by a rapid development of experimental …
Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an …
Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure
cases. It has features of incomplete relaxation and increased stiffness of the left ventricle …
cases. It has features of incomplete relaxation and increased stiffness of the left ventricle …
Organ‐level validation of a cross‐bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains
Although detailed cell‐based descriptors of cross‐bridge cycling have been applied in finite
element (FE) heart models to describe ventricular mechanics, these multiscale models have …
element (FE) heart models to describe ventricular mechanics, these multiscale models have …
Effects of persistent atrial fibrillation-induced electrical remodeling on atrial electro-mechanics–insights from a 3D model of the human atria
Aims Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful
cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical …
cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical …
Bioelectrical effects of mechanical feedbacks in a strongly coupled cardiac electro-mechanical model
P Colli Franzone, LF Pavarino… - Mathematical Models and …, 2016 - World Scientific
The aim of this work is to investigate by means of numerical simulations the effects of
myocardial deformation due to muscle contraction on the bioelectrical activity of the cardiac …
myocardial deformation due to muscle contraction on the bioelectrical activity of the cardiac …
Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study
P Colli Franzone, LF Pavarino… - Chaos: An Interdisciplinary …, 2017 - pubs.aip.org
In this work, we investigate the influence of cardiac tissue deformation on re-entrant wave
dynamics. We have developed a 3D strongly coupled electro-mechanical Bidomain model …
dynamics. We have developed a 3D strongly coupled electro-mechanical Bidomain model …
Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models
G Alrabghi, Y Liu, W Hu… - … Transactions of the …, 2023 - royalsocietypublishing.org
Previous studies have linked dysfunctional I to arising from mutations to KCND3-encoded
Kv4. 3 and KCND2-encoded Kv4. 2 to atrial fibrillation. Using computational models, this …
Kv4. 3 and KCND2-encoded Kv4. 2 to atrial fibrillation. Using computational models, this …
ECG imaging to detect the site of ventricular ischemia using torso electrodes: a computational study
Electrocardiography provides some information useful for ischemic diagnosis. However,
more recently there has been substantial growth in the area of ECG imaging, which by …
more recently there has been substantial growth in the area of ECG imaging, which by …
[HTML][HTML] In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics
A recent study has identified six novel genetic variations (D322H, E48G, A305T, D469E,
Y155C, P488S) in KCNA5 (encoding Kv1. 5 which carries the atrial-specific ultra-rapid …
Y155C, P488S) in KCNA5 (encoding Kv1. 5 which carries the atrial-specific ultra-rapid …
Joint influence of transmural heterogeneities and wall deformation on cardiac bioelectrical activity: A simulation study
The aim of this work is to investigate, by means of numerical simulations, the influence of
myocardial deformation due to muscle contraction and relaxation on the cardiac …
myocardial deformation due to muscle contraction and relaxation on the cardiac …