The bacterial spore as a mucosal vaccine delivery system

A Saggese, L Baccigalupi, G Donadio, E Ricca… - International Journal of …, 2023 - mdpi.com
The development of efficient mucosal vaccines is strongly dependent on the use of
appropriate vectors. Various biological systems or synthetic nanoparticles have been …

Application of Bacillus subtilis as a live vaccine vector: A review

P Lv, Y Song, C Liu, L Yu, Y Shang, H Tang… - Journal of Veterinary …, 2020 - jstage.jst.go.jp
Bacillus subtilis is widely used as a probiotic in various fields as it regulates intestinal flora,
improves animal growth performance, enhances body immunity, has short fermentation …

Searching for the one (s): Using probiotics as anthelmintic treatments

MP Saracino, CC Vila, PC Baldi… - Frontiers in …, 2021 - frontiersin.org
Helminths are a major health concern as over one billion people are infected worldwide
and, despite the multiple efforts made, there is still no effective human vaccine against them …

Gastrointestinal worms and bacteria: From association to intervention

J Rooney, C Cantacessi, J Sotillo… - Parasite …, 2023 - Wiley Online Library
A plethora of studies, both experimental and epidemiological, have indicated the occurrence
of associations between infections by gastrointestinal (GI) helminths and the composition …

Evaluation of immune response to Bacillus subtilis spores expressing Clonorchis sinensis serpin3

Z Lin, H Sun, Y Ma, X Zhou, H Jiang, X Wang, J Song… - Parasitology, 2020 - cambridge.org
Clonorchis sinensis (C. sinensis) is one of the most serious food-borne parasites, which can
lead to liver fibrosis or cholangiocarcinoma. Effective measures for clonorchiasis prevention …

Development of an oral nanovaccine for dogs against Echinococcus granulosus

M Leroux, U Benavides, I Hellel-Bourtal… - European Journal of …, 2023 - Elsevier
Dogs are the main source of animal and human cystic echinococcosis caused by the
Cestode parasite Echinococcus granulosus. Dog vaccination seems to be a good strategy to …

Spore-Based Probiotic Bacillus subtilis: Current Applications in Humans and Future Perspectives

N Williams, TL Weir - Fermentation, 2024 - mdpi.com
Bacillus subtilis has been used for more than 50 years in many different industrial
applications, including farming, precision fermentation, and probiotic supplements. It is …

Immunological prophylaxes for Echinococcus granulosus infection

W Zhang, J Li, D Liu - Molecular Medical Microbiology, 2024 - Elsevier
Echinococcus granulosus is a small zoonotic tapeworm that commonly affects dogs
(definitive hosts) and ruminants (intermediate hosts). Humans may acquire cystic …

The storage stability of Bacillus subtilis spore displaying cysteine protease of Clonorchis sinensis and its effect on improving the gut microbiota of mice

Z Tang, Z Wu, H Sun, L Zhao, M Shang, M Shi… - Applied Microbiology …, 2021 - Springer
Bacillus subtilis (B. subtilis) spore can serve as an ideal vehicle for expressing heterologous
antigens, and elicit specific immune responses by oral administration. In previous studies …

Recombinant HcGAPDH Protein Expressed on Probiotic Bacillus subtilis Spores Protects Sheep from Haemonchus contortus Infection by Inducing both Humoral and …

Y Yang, G Zhang, J Wu, X Chen, D Tong, Y Yang… - Msystems, 2020 - Am Soc Microbiol
Probiotic Bacillales are effective in controlling pathogens. Live probiotic bacteria improve the
composition of the gastrointestinal microbiota, leading to a reduction in pathogen …