Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

JX Cheng, XS Xie - Science, 2015 - science.org
BACKGROUND Biomolecules can serve as natural labels for microscopy by measuring their
molecular vibration spectra in living cells and tissues. However, the transition from …

Computational coherent Raman scattering imaging: breaking physical barriers by fusion of advanced instrumentation and data science

H Lin, JX Cheng - eLight, 2023 - Springer
Coherent Raman scattering (CRS) microscopy is a chemical imaging modality that provides
contrast based on intrinsic biomolecular vibrations. To date, endeavors on instrumentation …

Chemically sensitive bioimaging with coherent Raman scattering

CH Camp Jr, MT Cicerone - Nature photonics, 2015 - nature.com
Raman scattering provides an intrinsic fingerprint of chemical composition. Spontaneous
Raman spectroscopy has been used for many decades to interrogate biological materials …

High-speed coherent Raman fingerprint imaging of biological tissues

CH Camp Jr, YJ Lee, JM Heddleston, CM Hartshorn… - Nature …, 2014 - nature.com
An imaging platform based on broadband coherent anti-Stokes Raman scattering has been
developed that provides an advantageous combination of speed, sensitivity and spectral …

Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers

D Fu, G Holtom, C Freudiger, X Zhang… - The Journal of Physical …, 2013 - ACS Publications
Raman microscopy is a quantitative, label-free, and noninvasive optical imaging technique
for studying inhomogeneous systems. However, the feebleness of Raman scattering …

Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications

C Krafft, IW Schie, T Meyer, M Schmitt… - Chemical Society …, 2016 - pubs.rsc.org
First, the potential role of Raman-based techniques in biomedicine is introduced. Second,
an overview about the instrumentation for spontaneous and coherent Raman scattering …

Broadband coherent Raman scattering microscopy

D Polli, V Kumar, CM Valensise… - Laser & Photonics …, 2018 - Wiley Online Library
Spontaneous Raman (SR) microscopy allows label‐free chemically specific imaging based
on the vibrational response of molecules; however, due to the low Raman scattering cross …

Stimulated Raman scattering flow cytometry for label-free single-particle analysis

C Zhang, KC Huang, B Rajwa, J Li, S Yang, H Lin… - Optica, 2017 - opg.optica.org
Flow cytometry is one of the most important technologies for high-throughput single-cell
analysis. Fluorescent labeling acts as the primary approach for cellular analysis in flow …

Spatial homogeneity of pH in aerosol microdroplets

M Li, Y Kan, H Su, U Pöschl, SH Parekh, M Bonn… - Chem, 2023 - cell.com
Acidity plays a key role in atmospheric aerosol formation and strongly influences aerosols'
effects on air quality, climate, and the ecosystem. Fundamental questions about aerosol pH …

[HTML][HTML] Removing non-resonant background from CARS spectra via deep learning

CM Valensise, A Giuseppi, F Vernuccio… - APL Photonics, 2020 - pubs.aip.org
Broadband Coherent Anti-Stokes Raman Scattering (B-CARS) is a powerful label-free
nonlinear spectroscopy technique allowing one to measure the full vibrational spectrum of …