Means, mechanisms and consequences of adenine methylation in DNA

K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Autophagy in aging and longevity

SQ Wong, AV Kumar, J Mills, LR Lapierre - Human genetics, 2020 - Springer
Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …

Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution

Y Kong, L Cao, G Deikus, Y Fan, EA Mead, W Lai… - Science, 2022 - science.org
The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …

N6-deoxyadenosine methylation in mammalian mitochondrial DNA

Z Hao, T Wu, X Cui, P Zhu, C Tan, X Dou, KW Hsu… - Molecular cell, 2020 - cell.com
Summary N 6-Methyldeoxyadenosine (6mA) has recently been shown to exist and play
regulatory roles in eukaryotic genomic DNA (gDNA). However, the biological functions of …

[HTML][HTML] Piwi/PRG-1 argonaute and TGF-β mediate transgenerational learned pathogenic avoidance

RS Moore, R Kaletsky, CT Murphy - Cell, 2019 - cell.com
The ability to inherit learned information from parents could be evolutionarily beneficial,
enabling progeny to better survive dangerous conditions. We discovered that, after C …

The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels

Q Zhang, Z Wang, W Zhang, Q Wen, X Li, J Zhou… - Nature cell …, 2021 - nature.com
The memory of stresses experienced by parents can be passed on to descendants as a
forecast of the challenges to come. Here, we discovered that the neuronal mitochondrial …

Long-term impacts of preeclampsia on the cardiovascular system of mother and offspring

C Yang, PN Baker, JP Granger, ST Davidge… - Hypertension, 2023 - Am Heart Assoc
Preeclampsia is a pregnancy-specific complication that is associated with an increased
postpartum risk of cardiovascular disease (CVD) in both women and their offspring, although …

Mitocellular communication: Shaping health and disease

A Mottis, S Herzig, J Auwerx - Science, 2019 - science.org
Throughout the animal kingdom, mitochondria are the only organelles that retain their own
genome and the transcription and translation machineries that are all essential for energy …

METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

KW Hsu, JCY Lai, JS Chang, PH Peng, CH Huang… - Genome biology, 2022 - Springer
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …

[HTML][HTML] Mitochondrial complex I as a therapeutic target for Alzheimer's disease

E Trushina, S Trushin, MF Hasan - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has
no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau …