BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA
metabolism, including homologous recombination and mediating the replication stress …

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has
an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity …

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. By analyzing telomerase …

Tumours with mutations in the BRCA1/BRCA2 genes have impaired double-stranded DNA
break repair, compromised replication fork protection and increased sensitivity to replication …

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) to maintain
genomic integrity. Recombinase recruited to the DSBs by the mediator protein BRCA2 …

Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR).
In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here …

Over the decades, oxidative stress has emerged as a major concern to biological
researchers. It is involved in the pathogenesis of various lifestyle-related diseases such as …

Maintenance of genome integrity requires the functional interplay between Fanconi anemia
(FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a …

Alternative lengthening of telomeres (ALT) is a telomerase independent telomere
maintenance mechanism that occurs in∼ 15% of cancers. The potential mechanism of ALT …

Prostate-specific membrane antigen (PSMA) expression increases with prostate cancer
grade and progression; however, the role of PSMA in prostate cancer progression remains …