Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Genome packaging by nucleosomes is a hallmark of eukaryotes. Histones and the pathways
that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack …

Pericentromeric heterochromatin (PCH) gives rise to highly dense chromatin sub-structures
rich in the epigenetic mark corresponding to the trimethylated form of lysine 9 of histone H3 …

Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-
dimensional organization of chromosomes. However, there are currently no methods to …

The development of new technologies and experimental techniques is enabling researchers
to see what was once unable to be seen. For example, the centromere was first seen as the …

Recently interest in multi-generational epigenetic phenomena have been fuelled by highly
reproducible intergenerational and transgenerational inheritance paradigms in several …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

The centromeric histone 3 variant (CENH3, aka CENP-A) is essential for the segregation of
sister chromatids during mitosis and meiosis. To better define CENH3 functional constraints …

While short-read sequencing technology has resulted in a sharp increase in the number of
species with genome assemblies, these assemblies are typically highly fragmented …