Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

Heart failure is a progressive muscular disorder leading to a deterioration of the heart
characterized by a contractile dysfunction and a chronic energy deficit. As a consequence …

Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and
must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion …

Fibrosis is a general term encompassing a plethora of pathologies that span all systems and
is marked by increased deposition of collagen. Injury of variable etiology gives rise to …

Objective Accumulating evidence has implicated that GLP-1 may have a beneficial effect on
cardiovascular but the mechanism is not fully understood. Here we show that GLP-1 analog …

Abnormal cardiac metabolism or cardiac metabolic remodeling is reported before the onset
of heart failure with reduced ejection fraction (HFrEF) and is known to trigger and maintain …

AMP-activated protein kinase (AMPK), an evolutionarily conserved serine-threonine kinase
that senses cellular energy status, is activated by stress and neurohumoral stimuli. We …

Leptin is an adipocyte-derived hormone that regulates energy homeostasis. Leptin treatment
strikingly ameliorates metabolic disorders of lipodystrophy, which exhibits ectopic fat …

G-protein coupled receptors (GPCRs) comprise the largest and most diverse family of
membrane receptors in the human genome, relaying information from a vast array of …

The heart has a reduced capacity to generate sufficient energy when failing, resulting in an
energy-starved condition with diminished functions. Studies have identified numerous …