Innate Immunity to Mycobacterium tuberculosis

R van Crevel, THM Ottenhoff… - Clinical microbiology …, 2002 - Am Soc Microbiol
The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Lung remodeling in pulmonary tuberculosis

K Dheda, H Booth, JF Huggett… - The Journal of …, 2005 - academic.oup.com
Tuberculosis is a global public health catastrophe responsible for> 8 million cases of illness
and 2 million deaths annually. Pulmonary cavitation with cough-generated aerosol is the …

Depressed T-cell interferon-γ responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy

CS Hirsch, Z Toossi, C Othieno… - Journal of Infectious …, 1999 - academic.oup.com
Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency
virus (HIV)—uninfected and HIV-infected patients, with newly diagnosed pulmonary …

Assessment of interleukin‐6 in the pathogenesis of periodontal disease

K Takahashi, S Takashiba, A Nagai… - Journal of …, 1994 - Wiley Online Library
This study was performed to investigate the aspects of interleukin‐6 (IL‐6) production in both
the gingival tissue and the peripheral blood of patients with periodontal disease and of …

Thalidomide treatment reduces tumor necrosis factor α production and enhances weight gain in patients with pulmonary tuberculosis

JM Tramontana, U Utaipat, A Molloy, P Akarasewi… - Molecular …, 1995 - Springer
Background The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for
host immunity, but overproduction of this cytokine may have serious pathologic …

Acute‐phase response and the hypercoagulable state in pulmonary tuberculosis

SC Robson, NW White, I Aronson… - British journal of …, 1996 - Wiley Online Library
In our experience, severe pulmonary tuberculosis (PTB) is often complicated by deep
venous thrombosis (DVT). Because of the association between inflammation and …

Hemostatic changes in active pulmonary tuberculosis

O Turken, E Kunter, M Sezer… - … of Tuberculosis and …, 2002 - ingentaconnect.com
OBJECTIVE: Severe pulmonary tuberculosis (PTB) is sometimes complicated by deep vein
thrombosis (DVT). We have searched for possible hemostatic disturbances that are …

Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis.

K Law, M Weiden, T Harkin, K Tchou-Wong… - American journal of …, 1996 - atsjournals.org
Mycobacterium tuberculosis and its components have been shown to stimulate
mononuclear phagocytes in vitro to release interleukin-1 beta (IL-1 beta), tumor necrosis …

Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

CS Hirsch, R Hussain, Z Toossi… - Proceedings of the …, 1996 - National Acad Sciences
In tuberculosis, Mycobacterium tuberculosis (MTB)-stimulated T-cell responses are
depressed transiently, whereas antibody levels are increased. Lymphoproliferative …

Reduced Th17 Response in Patients with Tuberculosis Correlates with IL-6R Expression on CD4+ T Cells

X Chen, M Zhang, M Liao, MW Graner… - American Journal of …, 2010 - atsjournals.org
Rationale: Although it is well recognized that CD4+ T cells and T helper (Th) 1 cytokines are
critical in the cell-mediated response to Mycobacterium tuberculosis, it is also clear that this …