The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

In vivo near-infrared (NIR) fluorescence imaging is an emerging biomedical imaging
modality for use in both fundamental scientific research and clinical practice. Owing to …

We developed a new way to engineer complex proteins toward multidimensional
specifications using a simple, yet scalable, directed evolution strategy. By robotically picking …

While calcium imaging has become a mainstay of modern neuroscience, the spectral
properties of current fluorescent calcium indicators limit deep-tissue imaging as well as …

Plants are active contributors to the betterment of human living conditions and play a critical
role in ecological systems. During the process of plant growth and development, several …

Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein
tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We …

Synergistic advances in optical physics, probe design, molecular biology, labeling
techniques and computational analysis have propelled fluorescence imaging into new …

Phytochrome photoreceptors absorb far-red and near-infrared (NIR) light and regulate light
responses in plants, fungi, and bacteria. Their multidomain structure and autocatalytic …

Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of
targeted biological processes deep in tissues with high spatial resolution; however, high …

Light-mediated control of protein–protein interactions to regulate cellular pathways is an
important application of optogenetics. Here, we report an optogenetic system based on the …