Preclinical testing of living tissue-engineered heart valves for pediatric patients, challenges and opportunities

I Movileanu, M Harpa, H Al Hussein… - Frontiers in …, 2021 - frontiersin.org
Introduction: Pediatric patients with cardiac congenital diseases require heart valve implants
that can grow with their natural somatic increase in size. Current artificial valves perform …

Challenges in perioperative animal care for orthotopic implantation of tissue-engineered pulmonary valves in the ovine model

H Al Hussein, H Al Hussein, C Sircuta, OS Cotoi… - Tissue Engineering and …, 2020 - Springer
Background: Development of valvular substitutes meeting the performance criteria for
surgical correction of congenital heart malformations is a major research challenge. The …

[PDF][PDF] A novel manufactured system designed to ensure consistent conditions in mechanical preconditioning of ovine adipose derived stem cells differentiation toward …

I Movileanu, K Branzaniuc, A Chertes, T Preda… - Acta Medica …, 2019 - amtsibiu.ro
Introduction: Present valvular substitutes are imperfect prostheses. Regenerative medicine
imagines a viable prototype using stem cells, scaffolds and bioreactors. In our study we …