Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a
group of neurodegenerative disorders including Parkinson's disease (PD). Although its role …

Lipids play a vital role in the health and functioning of neurons and interest in the
physiological role of neuronal lipids is certainly increasing. One neuronal function in which …

The amyloid aggregation of α-synuclein (α S), related to Parkinson's disease, can be
catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and …

The interaction of the neuronal protein α-synuclein with lipid membranes appears crucial in
the context of Parkinson's disease, but the underlying mechanistic details, including the …

The onset of Alzheimer's disease (AD) is triggered by the aggregation of amyloid β (Aβ)
peptides which leads to the formation of fibrils. Molecules that are able to inhibit fibrillation …

Several environmental pollutants, including pesticides, herbicides and persistent organic
pollutants play an important role in the development of chronic diseases. However, most …

In the central nervous system, lipids represent approximately 70% of myelin dry weight and
play a key role in axon insulation and action potential conduction velocity. Lipids may thus …

Oligomeric species formed during α-synuclein fibrillation are suggested to be membrane-
disrupting agents, and have been associated with cytotoxicity in Parkinson's disease. The …

Despite extensive studies of the effects of herbal-derived small molecules in the
biopharmaceutical and biomedical sciences, their low solubility and stability remain a …

Alpha-synuclein is an intrinsically disordered protein whose formation of beta-sheet-rich
protein aggregates in the brain is implicated in the development of Parkinson's disease. Due …