Phosphate is an essential macronutrient for fungal proliferation as well as a key mediator of
antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In …

Caffeine, a methylxanthine analog of purine bases, is a compound that is largely consumed
in beverages and medications for psychoactive and diuretic effects and plays many …

Cryptococcal disease is estimated to affect nearly a quarter of a million people annually.
Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical …

Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens,
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …

New antifungals with unique modes of action are urgently needed to treat the increasing
global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) …

In Saccharomyces cerevisiae, inositol polyphosphate kinase KCS1 but not VIP1 knockout is
of great significance for maintaining cell viability, promoting glycolysis metabolism, and …

Aspergillus fumigatus is a ubiquitous saprophytic mold that can cause a range of clinical
syndromes, from allergic reactions to invasive infections. Amphotericin B (AMB) is a polyene …

Adaptation to the host environment is crucial for fungal pathogenesis. Calcium (Ca 2+)
signals are essential for fungal cells to respond rapidly to stress stimuli. In eukaryotic cells …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclindependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …