The introduction of MINFLUX nanoscopy allows single molecules to be localized with one
nanometer precision in as little as one millisecond. However, current applications have so …

Timely diagnosis of acute diseases improves treatment outcomes and saves lives, but it
requires fast and precision quantification of biomarkers. Here, we report a time-resolved …

Cell status changes are typically accompanied by the simultaneous changes of multiple
microRNA (miRNA) levels. Thus, simultaneous and ultrasensitive detection of multiple …

A rapid and sensitive method to detect cardiac troponin I (cTnI) in human blood is critical to
the diagnosis and treatment of acute myocardial infarction (AMI). Here, we describe a simple …

A fully Integrated Micropillar Polydimethylsiloxane Accurate CRISPR deTection (IMPACT)
system is developed for viral DNA detection. This powerful system is patterned with high …

Aberrant DNA methylation by DNA methyltransferases (MTase) is related to the initiation and
progression of many diseases. Thus, site-specific identification of DNA methylation and …

The oligomeric state of plasma membrane proteins is the result of the interactions between
individual subunits and an important determinant of their function. Most approaches used to …

Spontaneously blinking fluorophores, a class of molecules switching rapidly between a dark
and a brightly emitting state, have emerged as a popular core to build fluorescent markers …

The rise of antibiotic resistance poses a significant and ongoing challenge to public health,
with pathogenic bacteria remaining a persistent threat. Traditional culture methods, while …

Voltage program (VP)-based micellar electrokinetic chromatography (MEKC) with a laser-
induced fluorescence (LIF) detector was developed for fast, high-sensitivity detection of …