Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

As humans age, the risk and severity of infections vary in line with immune competence
according to how the immune system develops, matures, and declines. Several factors …

Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …

Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …

Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged
cells, preventing their propagation in tissues. However, senescent cells accumulate in …

When facing an acute viral infection, our immune systems need to function with finite
precision to enable the elimination of the pathogen, whilst protecting our bodies from …