The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …

Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key
insights into adaptive immune responses, but the accuracy of current TCR sequencing …

The T cell receptor (TCR) repertoire is pivotal to the human immune system, and
understanding its nuances can significantly enhance our ability to forecast cancer-related …

Sparked by the development of genome sequencing technology, the quantity and quality of
data handled in immunological research have been changing dramatically. Various data …

The complexity of entire T cell receptor (TCR) repertoires makes their comparison a difficult
but important task. Current methods of TCR repertoire comparison can incur a high loss of …

B cell receptors (BCRs) and T cell receptors (TCRs) make up an essential network of
defense molecules that, collectively, can distinguish self from non-self and facilitate …

Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD),
and current dogma dictates that this is driven by histocompatibility antigen disparities …

The adaptive immune system generates an incredible diversity of antigen receptors for B
and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these …

Depletion of CD4+ cells using an anti-CD4 monoclonal antibody (anti-CD4 mAb) induces
the expansion of tumor-reactive CD8+ T cells and strong antitumor effects in several murine …