Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

P Jain, BC Weinrick, EJ Kalivoda, H Yang, V Munsamy… - MBio, 2016 - Am Soc Microbiol
Persisters are the minor subpopulation of bacterial cells that lack alleles conferring
resistance to a specific bactericidal antibiotic but can survive otherwise lethal concentrations …

Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in Ex Vivo and In Vivo Survival

S Kumar, MZ Khan, N Khandelwal, C Chongtham… - Mbio, 2022 - Am Soc Microbiol
Mycobacterium tuberculosis encodes~ 200 transcription factors that modulate gene
expression under different microenvironments in the host. Even though high-throughput …

Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis

RK Donegan, Y Fu, J Copeland, S Idga… - Microbiology …, 2022 - Am Soc Microbiol
Heme is both an essential cofactor and an abundant source of nutritional iron for the human
pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival …

A nonribosomal peptide synthase gene driving virulence in Mycobacterium tuberculosis

K Bhatt, H Machado, NS Osório, J Sousa, F Cardoso… - Msphere, 2018 - Am Soc Microbiol
Nonribosomal peptide synthases produce short peptides in a manner that is distinct from
classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis …

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose

M Boot, VJC van Winden, M Sparrius… - PLoS …, 2017 - journals.plos.org
The cell envelope of mycobacteria is a highly unique and complex structure that is
functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects …

Identification, assessment and optimisation of key impact variables in people analytics using AI

J Kameswari, H Palivela, S Settur… - The Adoption and Effect of …, 2023 - emerald.com
Background: Human resource management (HRM) is the tactical method for a business
enterprise's optimistic and systemic administration. This study aims to identify the common …

Development of a counterselectable transposon to create markerless knockouts from an 18,432-clone ordered Mycobacterium bovis Bacillus Calmette-Guerin mutant …

K Borgers, K Vandewalle, A Van Hecke, G Michielsen… - Msystems, 2020 - Am Soc Microbiol
Mutant resources are essential to improve our understanding of the biology of slow-growing
mycobacteria, which include the causative agents of tuberculosis in various species …

The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

C Xander, S Rajagopalan, WR Jacobs Jr… - Infection and …, 2024 - Am Soc Microbiol
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that survives and grows in
macrophages. A mechanism used by Mtb to achieve intracellular survival is to secrete …

Lack of specificity of phenotypic screens for inhibitors of the Mycobacterium tuberculosis FAS-II system

AE Grzegorzewicz, J Lelièvre, J Esquivias… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Phenotypic screening of inhibitors of the essential Mycobacterium tuberculosis FAS-II
dehydratase HadAB led to the identification of GSK3011724A, a compound previously …

Use of a counterselectable transposon to create markerless knockouts from a 18,432-clone ordered M. bovis BCG mutant resource

K Borgers, K Vandewalle, A Van Hecke, G Michielsen… - bioRxiv, 2019 - biorxiv.org
Mutant resources are essential to improve our understanding of the biology of slow-growing
mycobacteria, which include the causative agents of tuberculosis in various species …