Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …

Abstract ProteomicsDB (https://www. ProteomicsDB. org) started as a protein-centric in-
memory database for the exploration of large collections of quantitative mass spectrometry …

Artificial intelligence and machine learning (ML) promise to transform cancer therapies by
accurately predicting the most appropriate therapies to treat individual patients. Here, we …

The laboratory mouse ranks among the most important experimental systems for biomedical
research and molecular reference maps of such models are essential informational tools …

Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is
molecularly not understood. This disconnect is particularly apparent in cancer entities such …

Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer
cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action …

Given the rapidly decreasing cost and increasing speed and accessibility of massively
parallel technologies, the integration of comprehensive genomic, transcriptomic, and …