Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …

Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic
metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Xenobiotics have been defined as chemicals to which an organism is exposed that are
extrinsic to the normal metabolism of that organism. Without metabolism, many xenobiotics …

The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …

Owing to environmental health concerns, a number of per-and polyfluoroalkyl substances
(PFAS) have been phased-out, and increasingly replaced by various chemical analogs …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …