Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic
output. Over time, chemical discovery efforts for kinases have produced ATP-competitive …

Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

We elucidate the molecular mechanisms of two distinct activation strategies
(autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic …

Determining mechanisms of drug action in human cells remains a major challenge. Here we
describe an approach in which multiple-drug-resistant clones are isolated and transcriptome …

Aurora kinases are essential for cell division and are frequently misregulated in human
cancers. Based on their potential as cancer therapeutics, a plethora of small molecule …

Aurora kinase family of serine/threonine kinases are important regulators of mitosis that are
frequently over expressed in human cancers and have been implicated in oncogenic …

The correct assembly and timely disassembly of the mitotic spindle is crucial for the
propagation of the genome during cell division. Aurora kinases play a central role in …

Protein kinases are activated by phosphorylation and by the binding of activator proteins.
The interplay of these two factors is incompletely understood. We applied energetic analysis …