Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications

E Papachristoforou, V Lambadiari… - Journal of diabetes …, 2020 - Wiley Online Library
Oxidative stress (OS) is defined as a disturbance in the prooxidant‐antioxidant balance of
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …

Oxidative stress: Concept and some practical aspects

H Sies - Antioxidants, 2020 - mdpi.com
Oxidative stress is defined as “an imbalance between oxidants and antioxidants in favor of
the oxidants, leading to a disruption of redox signaling and control and/or molecular …

How leisure activities affect health: a narrative review and multi-level theoretical framework of mechanisms of action

D Fancourt, H Aughterson, S Finn, E Walker… - The Lancet …, 2021 - thelancet.com
There is a large and growing body of evidence on the health benefits of engagement in
leisure activities (voluntary, enjoyable non-work activities, such as hobbies, arts …

[HTML][HTML] The evolution of the concept of stress and the framework of the stress system

S Lu, F Wei, G Li - Cell stress, 2021 - ncbi.nlm.nih.gov
Stress is a central concept in biology and has now been widely used in psychological,
physiological, social, and even environmental fields. However, the concept of stress was …

[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis

H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

[HTML][HTML] Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

H Sies - Redox biology, 2017 - Elsevier
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Loneliness in the modern age: An evolutionary theory of loneliness (ETL)

JT Cacioppo, S Cacioppo - Advances in experimental social psychology, 2018 - Elsevier
Abstract We describe the Cacioppo Evolutionary Theory of Loneliness (ETL) and its
manifestations in contemporary society. The early conceptualizations of loneliness were as …

[HTML][HTML] Chronic stress as a risk factor for Alzheimer's disease: roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress

K Bisht, K Sharma, MÈ Tremblay - Neurobiology of stress, 2018 - Elsevier
Microglia are the predominant immune cells of the central nervous system (CNS) that exert
key physiological roles required for maintaining CNS homeostasis, notably in response to …