Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Mitophagy in tumorigenesis and metastasis

LP Poole, KF Macleod - Cellular and molecular life sciences, 2021 - Springer
Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

Plasma markers of disrupted gut permeability in severe COVID-19 patients

LB Giron, H Dweep, X Yin, H Wang, M Damra… - Frontiers in …, 2021 - frontiersin.org
A disruption of the crosstalk between the gut and the lung has been implicated as a driver of
severity during respiratory-related diseases. Lung injury causes systemic inflammation …

Molecular mechanisms and regulation of mammalian mitophagy

V Choubey, A Zeb, A Kaasik - Cells, 2021 - mdpi.com
Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …

[HTML][HTML] Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling

LB Giron, MJ Peluso, J Ding, G Kenny, NF Zilberstein… - JCI insight, 2022 - ncbi.nlm.nih.gov
Long COVID, a type of post-acute sequelae of SARS-CoV-2 (PASC), has been associated
with sustained elevated levels of immune activation and inflammation. However, the …

PANoptosis: Mechanisms, biology, and role in disease

X Sun, Y Yang, X Meng, J Li, X Liu… - Immunological …, 2024 - Wiley Online Library
Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …

FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM

Y Bi, H Xu, X Wang, H Zhu, J Ge, J Ren, Y Zhang - Cell death & disease, 2022 - nature.com
Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its
life-threatening cardiotoxicity severely limiting its clinical application. Mitochondrial damage …

Mitochondrial quality control proteases and their modulation for cancer therapy

J Zhang, W Qiao, Y Luo - Medicinal Research Reviews, 2023 - Wiley Online Library
Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

[HTML][HTML] Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIδ pathway in vitro and in vivo

Z Song, H Song, D Liu, B Yan, D Wang, Y Zhang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The continued success of oncological therapeutics is dependent on the
mitigation of treatment-related adverse events, particularly cardiovascular toxicities. As such …

Mitochondrial fission and fusion in tumor progression to metastasis

DP Boulton, MC Caino - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Mitochondria are highly dynamic organelles which can change their shape, via processes
termed fission and fusion, in order to adapt to different environmental and developmental …