Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …

Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity.
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …

Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

Immunotherapy has achieved revolutionary success in clinics, but it remains challenging for
treating hepatocellular carcinoma (HCC) characterized by high vascularization. Here, it is …

Although targeting the tumor metabolism is performed in cooperation with immunotherapy in
the era of precision oncology, ignorance of immune cells' metabolism has resulted in …

With the economy's globalization and the population's aging, cancer has become the
leading cause of death in most countries. While imposing a considerable burden on society …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Endothelial cell (EC) injury plays a key role in the chronic wound process. A long-term
hypoxic microenvironment hinders the vascularization of ECs, thus delaying wound healing …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …