Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …

Quinolones are one of the most commonly prescribed classes of antibacterials in the world
and are used to treat a variety of bacterial infections in humans. Because of the wide use …

DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …

Topoisomerases are complex molecular machines that modulate DNA topology to maintain
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …

Despite the success of genomics in identifying new essential bacterial genes, there is a lack
of sustainable leads in antibacterial drug discovery to address increasing multidrug …

Type II topoisomerases (TOP2s) resolve the topological problems of DNA by transiently
cleaving both strands of a DNA duplex to form a cleavage complex through which another …

Enzymes are highly evolved catalysts that perform their tasks with high efficiency. 1 Hence,
they may constitute a very attractive reference in the development of a synthetic catalyst. The …

DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …

Abstract ε-Poly-lysine (ε-PL) is widely recognized as a natural antibacterial agent because of
its broad spectrum antimicrobial property. However, the mechanism of ε-PL against …

The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar
bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However …