RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …

Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA …

Many years of extensive studies of metazoan mitochondrial genomes have established
differences in gene arrangements and genetic codes as valuable phylogenetic markers …

Known disease mechanisms in mitochondrial DNA (mtDNA) maintenance disorders alter
either the mitochondrial replication machinery (POLG, POLG2 and C10orf2),, or the …

Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability
as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of …

Elucidation of the process of DNA replication in mitochondria is in its infancy. For many
years, maintenance of the mitochondrial genome was regarded as greatly simplified …

R-loops are stable chromatin structures comprising a DNA: RNA hybrid and a displaced
single-stranded DNA. R-loops have been implicated in gene expression and chromatin …

While the majority of DNA is enclosed within the nucleus, the mitochondria also contain their
own, separate DNA, the mitochondrial DNA (mtDNA). Mutations in mtDNA are associated …