The scaffold protein AXIN1: gene ontology, signal network, and physiological function

L Qiu, Y Sun, H Ning, G Chen, W Zhao… - Cell Communication and …, 2024 - Springer
AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin
signaling pathway, and subsequently unveiled its integral involvement across a diverse …

Exosome‐Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration

B Yin, Q Ma, C Song, L Zhao, F Yu… - Stem Cells …, 2021 - Wiley Online Library
The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery.
The current treatments including autologous and allogenic bone grafting and bioactive …

KPT-330 prevents aortic valve calcification via a novel C/EBPβ signaling pathway

P Dutta, KM Kodigepalli, S LaHaye… - Circulation …, 2021 - Am Heart Assoc
Rationale: Calcific aortic valve disease (CAVD) affects> 5.2 million people in the United
States. The only effective treatment is surgery, and this comes with complications and no …

[HTML][HTML] Root bark of Morus alba L. and its bioactive ingredient, ursolic acid, suppress the proliferation of multiple myeloma cells by inhibiting wnt/β-catenin pathway

GR Song, YJ Choi, SJ Park, S Shin, G Lee… - … of Microbiology and …, 2021 - ncbi.nlm.nih.gov
The root bark of Morus alba L. has cytotoxic activity against several types of cancer cells.
However, little is known about its chemopreventive mechanisms and bioactive metabolites …

UBE3C promotes proliferation and inhibits apoptosis by activating the β-catenin signaling via degradation of AXIN1 in gastric cancer

Y Zhang, J Xu, H Fu, Z Wei, D Yang, R Yan - Carcinogenesis, 2021 - academic.oup.com
Gastric cancer (GC) remains one of the most frequent cancers worldwide. Previous studies
have shown that E3 ubiquitin ligase E3C (UBE3C) promotes the progression of multiple …

Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria

T Ikeda, S Watanabe, T Mitani - Bioscience, Biotechnology, and …, 2022 - academic.oup.com
Genistein exerts antiadipogenic effects, but its target molecules remain unclear. Here, we
delineated the molecular mechanism underlying the antiadipogenic effect of genistein. A …

Identification of a vital transcription factor of the alanine aminotransferase in the brown planthopper and its upstream regulatory pathways

LQ Wang, SH Li, WQ Zhang - Insect Biochemistry and Molecular Biology, 2024 - Elsevier
The brown planthopper (Nilaparvata lugens) is an important insect pest of rice, and can
rapidly adapt to insect-resistant rice varieties. In our previous studies, alanine …

Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath

X Zheng, H Huang, Z Zhou, W Guo, G Yang… - …, 2024 - journals.biologists.com
Hertwig's epithelial root sheath (HERS) interacts with dental apical mesenchyme and guides
development of the tooth root, which is integral to the function of the whole tooth. However …

CCAAT enhancer-binding protein α suppresses proliferation, metastasis, and epithelial-mesenchymal transition of ovarian cancer cells via suppressing the Wnt/β …

LM Zhang, LI Mo, T Chen-Chen, W Tong-Tong… - …, 2021 - search.ebscohost.com
CCAAT enhancer-binding protein alpha (CEBPA, also known as C/EBPα) is a transcription
factor that plays an essential role in regulating terminal differentiation and cell proliferation of …

A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function

I Samuelson - 2020 - repository.cam.ac.uk
Obesity and associated metabolic complications are growing health challenges in today's
society. New therapies, which do not rely on surgical interventions, are required to treat …