Gene electrotransfer is a powerful method of DNA delivery offering several medical
applications, among the most promising of which are DNA vaccination and gene therapy for …

Diverse cellular processes are driven by the collective force from multiple motor proteins.
Disease-causing mutations cause aberrant function of motors, but the impact is observed at …

Many cellular processes require large forces that are generated collectively by multiple
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …

Electroporation is a physical method of transferring molecules into cells and tissues. It takes
advantage of the transient permeabilization of the cell membrane induced by electric field …

Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor
critical for cell division. Dynein is essential for the formation and positioning of the mitotic …

Recent experiments have demonstrated that dynein motors exhibit catch bonding behavior,
in which the unbinding rate of a single dynein decreases with increasing force, for a certain …

Motor-driven intracellular transport is a complex phenomenon where multiple motor proteins
simultaneously attached on to a cargo engage in pulling activity, often leading to tug-of-war …

Intracellular bidirectional transport of cargo on microtubule filaments is achieved by the
collective action of oppositely directed dynein and kinesin motors. Experiments have found …

The mechanisms involved in bidirectional transport along microtubules remain largely
unknown. We explored the collective action of kinesin-2 and dynein motors during transport …

Molecular motors such as kinesin and dynein are responsible for transporting material along
microtubule networks in cells. In many contexts, motor dynamics can be modelled by a …