Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Protease-targeted chimeras (PROTACs) are a new technology that is receiving much
attention in the treatment of diseases. The mechanism is to inhibit protein function by …

Major depressive disorder is a devastating mental disorder. Current antidepressant
medications can be effective for some patients with depression; however, these drugs exert …

Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …

Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates
the elongation stage of protein synthesis by phosphorylating and inhibiting its only known …

Neuronal activity results in long lasting changes in synaptic structure and function by
regulating mRNA translation in dendrites. These activity dependent events yield the …

Eukaryotic elongation factor 2 kinase (eEF2K), an atypical calmodulin-dependent protein
kinase, phosphorylates and inhibits eEF2, slowing down translation elongation. eEF2K …

Hepatocellular carcinoma (HCC) is an aggressive malignancy with increasing mortality in
China. Angiogenesis is crucial for tumor formation, development and metastasis in HCC …

The group of enteroviruses contains many important pathogens for humans, including
poliovirus, coxsackievirus, rhinovirus, as well as newly emerging global health threats such …

Eukaryotic elongation factor 2 kinase (eEF2K) is a highly unusual protein kinase that
negatively regulates the elongation step of protein synthesis. This step uses the vast majority …