The structure-based design introduced indoles as an essential motif in designing new
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …

FMS‐like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid
leukemia (AML) patients. In the current study, the oxindole chemotype is employed as a …

The use of covalent irreversible binding inhibitors is an established concept for drug
development. Usually, the discovery of new irreversible kinase inhibitors occurs …

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1, 4‐
conjugate reductions of α, β‐unsaturated carbonyl compounds, which features operational …

The free fatty acid receptor 1 (FFA1), a G protein-coupled receptor (GPCR) naturally
activated by long-chain fatty acids is a novel target for the treatment of metabolic diseases …

The most prevalent leucine-rich repeat kinase 2 (LRRK2) mutation G2019S is associated
with Parkinson's disease (PD). It enhances kinase activity and has been identified in both …

Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-
oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase …

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell
physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor …

Efficient multigram two-step syntheses of 4-(2-chloroethoxy) phenol and 4-(3-chloropropoxy)
phenol in> 70% yields starting from 4-hydroxybenzaldehyde and reagents with general …

A series of cationic boron dipyrromethene (BODIPY) derivatives were synthesized and
characterized with various spectroscopic methods. Having the ability to generate singlet …