Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

The crucial balance of stability in blood-circulation and tumor-specific delivery has been
suggested as one of the challenges for effective bench-to-bedside translation of …

Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor
prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical …

The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-
steroidal anti-inflammatory pain reliever. As drug design progressed, the ability of AAI …

Microtubules are appealing as intracellular targets for anticancer activity due to their
importance in cell division. Three important binding sites are present on the tubulin protein …

Background Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do
not cross the blood brain barrier (BBB). To address this limitation, we developed the new …

Small molecules that target microtubules (MTs) represent promising therapeutics to treat
certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified …

In the development of novel and more effective anticancer approaches, combined
treatments appear to be of great interest, based on the possibility of obtaining relevant …