The highly reproducible inheritance of chromosomes during mitosis in mammalian cells
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …

Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …

Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer
(GC). Understanding the upstream regulation of immune checkpoints is crucial to further …

TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes
stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is …

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer
development and progression, including the metastatic spread of disease. Through in silico …

Tumor suppression by inducing NCOA4-mediated ferroptosis has been shown to be feasible
in a variety of tumors, including gliomas. However, the regulatory mechanism of ferroptosis …

Transcription factors play critical roles in regulation of neural development and functions. A
transcription factor Mblk-1 was previously reported from a screen for factors possibly …

Ligand-dependent corepressor (LCoR) is a transcriptional repressor of ligand-activated
estrogen receptors (ERs) and other transcription factors that acts both by recruiting histone …

Mitochondria-mediated apoptosis is the primary cause of cardiomyocyte death. Therefore,
mitochondria are a key target for treating myocardial injury. Mitochondrial calcium uniporter …

Although greater than 90% of breast cancer-related mortality can be attributed to
metastases, the molecular mechanisms underpinning the dissemination of primary breast …