Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades are presented, with an emphasis on the deciphering of the activation mechanism, the …
Advances in the field of boron chemistry have expanded the application of this element in Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of …
MP Silva, L Saraiva, M Pinto, ME Sousa - Molecules, 2020 - mdpi.com
Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been …
Introduction: Of the 15 human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms known to date, for 11 the crystal structure is known. Many different classes of CA inhibitors (CAIs) were …
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
X Wang, IS Mohammad, L Fan, Z Zhao… - … Pharmaceutica Sinica B, 2021 - Elsevier
Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among …
The incorporation of the “magic” boron atom has been established as an important new strategy in the field of medicinal chemistry as boron compounds have been shown to form …
EA Dickie, F Giordani, MK Gould, P Mäser… - Tropical medicine and …, 2020 - mdpi.com
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs …