The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry
K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …
functional groups in medicinal chemistry applications are discussed. This includes …
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Boron in drug design: Recent advances in the development of new therapeutic agents
Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …
biochemical and physiological changes, which frequently influence the outcome of …
Boronic acids and their derivatives in medicinal chemistry: synthesis and biological applications
MP Silva, L Saraiva, M Pinto, ME Sousa - Molecules, 2020 - mdpi.com
Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …
Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery
A Nocentini, CT Supuran - Expert Opinion on Drug Discovery, 2019 - Taylor & Francis
Introduction: Of the 15 human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms known to date,
for 11 the crystal structure is known. Many different classes of CA inhibitors (CAIs) were …
for 11 the crystal structure is known. Many different classes of CA inhibitors (CAIs) were …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
[HTML][HTML] Delivery strategies of amphotericin B for invasive fungal infections
X Wang, IS Mohammad, L Fan, Z Zhao… - … Pharmaceutica Sinica B, 2021 - Elsevier
Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage
in many medical settings, with substantial associated morbidities and mortalities. Among …
in many medical settings, with substantial associated morbidities and mortalities. Among …
Boron-Containing heterocycles as promising pharmacological agents
The incorporation of the “magic” boron atom has been established as an important new
strategy in the field of medicinal chemistry as boron compounds have been shown to form …
strategy in the field of medicinal chemistry as boron compounds have been shown to form …
New drugs for human African trypanosomiasis: a twenty first century success story
EA Dickie, F Giordani, MK Gould, P Mäser… - Tropical medicine and …, 2020 - mdpi.com
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …