The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Schizophrenia is often referred to as one of the most severe mental disorders, primarily
because of the very high mortality rates of those with the disorder. This article reviews the …

Resting-state fMRI (rs-fMRI) has emerged as an alternative method to study brain function in
human and animal models. In humans, it has been widely used to study psychiatric …

Neurocognitive deficits are evident both in established schizophrenia and bipolar disorder
(BP). However, it has been suggested that schizophrenia, but not BP, is characterized by …

Recent genetic studies reinforce the view that current approaches to the diagnosis and
classification of major psychiatric illness are inadequate. These findings challenge the …

Gene–environment interplay is a general term that covers several divergent concepts with
different meanings and different implications. In this review, we evaluate research evidence …

The possible mechanisms involved in continuities and discontinuities in psychopathology
between childhood and adult life are considered in relation to the findings from systematic …

Context Most societies believe that a mother's psychological state can influence her unborn
baby. Severe adverse life events during pregnancy have been consistently associated with …

BackgroundPrevious work suggests that impairments in executive function and verbal
memory in particular may persist in euthymic bipolar patients and serve as an indicator of …

There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …