Mapping the genomic diaspora of gastric cancer
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
[HTML][HTML] Genetics and molecular pathogenesis of gastric adenocarcinoma
Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …
cancer death. A complex disease arising from the interaction of environmental and host …
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
Multiancestry genomic and transcriptomic analysis of gastric cancer
Y Totoki, M Saito-Adachi, Y Shiraishi, D Komura… - Nature …, 2023 - nature.com
Gastric cancer is among the most common malignancies worldwide, characterized by
geographical, epidemiological and histological heterogeneity. Here, we report an extensive …
geographical, epidemiological and histological heterogeneity. Here, we report an extensive …
[HTML][HTML] Molecular classification of gastric cancer
Gastric cancer (GC), a heterogeneous disease characterized by epidemiologic and
histopathologic differences across countries, is a leading cause of cancer-related death …
histopathologic differences across countries, is a leading cause of cancer-related death …
Association of MUC16 mutation with tumor mutation load and outcomes in patients with gastric cancer
Importance MUC16, which encodes cancer antigen 125 (CA-125), is frequently mutated in
gastric cancer (GC); however, its association with tumor mutation load (TML) and outcome in …
gastric cancer (GC); however, its association with tumor mutation load (TML) and outcome in …
Update on gastric cancer treatments and gene therapies
A Biagioni, I Skalamera, S Peri, N Schiavone… - Cancer and Metastasis …, 2019 - Springer
Gastric cancer is an active topic of clinical and basic research due to high morbidity and
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …
Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship
M Piscione, M Mazzone, MC Di Marcantonio… - Frontiers in …, 2021 - frontiersin.org
Worldwide, gastric cancer (GC) represents the fifth cancer for incidence, and the third as
cause of death in developed countries. Indeed, it resulted in more than 780,000 deaths in …
cause of death in developed countries. Indeed, it resulted in more than 780,000 deaths in …
The yin and yang of ERBB4: tumor suppressor and oncoprotein
Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …