At present, nine adrenoceptor (AR) subtypes have been identified: α1A-, α1B-, α1D-, α2A-,
α2B-, α2C-, β1-, β2-, and β3AR. In the human heart, β1-and β2AR are the most powerful …

The human genome encodes nine different adrenoceptor genes. These are grouped into
three families, namely, the α 1-, α 2-, and β-adrenoceptors, with three family members each …

β-1 and β-2 adrenoceptors (AR) play a pivotal role in regulation of the activity of the
sympathetic nervous system and agonists and antagonists at both β AR subtypes are …

Pharmacogenetics, the inherited basis for interindividual differences in drug response, has
rapidly expanded with the advent of new molecular tools and the sequencing of the human …

There can be no doubt that β 1-, β 2-and β 3-adrenoceptor genes have genetic
polymorphisms. Two single nucleotide polymorphisms have been described for the β 1 …

Heart Failure (HF) is a common disorder associated with substantial morbidity and mortality.
β adrenergic receptors (βAR) are the primary pathway through which cardiac function is …

Abstract β1‐and β2‐Adrenoceptors (AR) play a pivotal role in regulation of the
cardiovascular system. Both β‐AR subtypes are polymorphic. There are two major single …

Heart failure is a complex clinical syndrome. There is evidence for a genetic contribution to
the pathophysiology of heart failure. Considering the fundamental role of neurohormonal …

Beta1-adrenergic receptor polymorphisms have been implicated with inconsistent results in
the pathogenesis, clinical presentation, and prognosis of patients with heart failure (HF). The …

BACKGROUND: We sought to investigate the relation between the Arg389Gly
polymorphism in the human β1-adrenergic receptor (ADRB1) gene and acute myocardial …