The WHO 2007 glioma classification system (based primarily on tumour histology) resulted
in considerable interobserver variability and substantial variation in patient survival within …

Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …

The recent identification of IDH mutations in gliomas and several other cancers suggests
that this pathway is involved in oncogenesis; however effector functions are complex and yet …

Background Primary and adaptive resistance against chemo-and radiotherapy and local
recurrence after surgery limit the benefits from these standard treatments in glioma patients …

For many intraoperative decisions surgeons depend on frozen section pathology, a
technique developed over 150 y ago. Technical innovations that permit rapid molecular …

Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in
young, otherwise healthy patients and generally have an indolent course with longer-term …

Importance Over the past 4 years, our understanding of gliomagenesis and the practice of
neuro-oncology have been radically changed by the discovery of mutations involving the …

Background Traditional classification of diffuse infiltrating gliomas (DIGs) as World Health
Organization (WHO) grades II-IV is based on histological features of a heterogeneous …

The tumors classified as gliomas include a wide variety of histologies including the more
common (astrocytoma, glioblastoma), as well as the less common histologies …

Background Genetic and epigenetic profiling of glioblastomas has provided a
comprehensive list of altered cancer genes of which only O6-methylguanine …