Targeting PPARs for therapy of atherosclerosis: A review

M Miao, X Wang, T Liu, YJ Li, WQ Yu, TM Yang… - International journal of …, 2023 - Elsevier
Atherosclerosis, a chief pathogenic factor of cardiovascular disease, is associated with many
factors including inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator …

[HTML][HTML] Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease

J Pan, W Zhou, R Xu, L Xing, G Ji, Y Dang - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases
including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely …

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured HT22 …

S Yang, Z Xie, T Pei, Y Zeng, Q Xiong, H Wei, Y Wang… - Chinese Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a
critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is …

Hepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell EMT process: a crosstalk between hepatocytes and hepatic stellate cells

Z Lang, Y Li, L Lin, X Li, Q Tao, Y Hu, M Bao… - Cell Death …, 2023 - nature.com
Abstract Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell
(HSC) activation, a crucial event for liver fibrosis. Moreover, Sal has been reported to …

Peroxisome proliferator-activated receptor-γ as a target and regulator of epigenetic mechanisms in nonalcoholic fatty liver disease

M Zaiou - Cells, 2023 - mdpi.com
Peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the superfamily of nuclear
receptors that control the transcription of multiple genes. Although it is found in many cells …

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer

Y Zheng, Z Zhou, G Wang, J Tu, H Cheng, S Ma… - Cell Death & …, 2023 - nature.com
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low.
MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with …

A comprehensive review of miR-21 in liver disease: Big impact of little things

X Xue, Y Li, Y Yao, S Zhang, C Peng, Y Li - International …, 2024 - Elsevier
Abstract microRNAs (miRNAs), a class of non-coding RNA with 20–24 nucleotides, are
defined as the powerful regulators for gene expression. miR-21 is a multifunctional miRNA …

[HTML][HTML] Royal Jelly Exerts a Potent Anti-Obesity Effect in Rats by Activating Lipolysis and Suppressing Adipogenesis

AH Felemban, GM Alshammari, AEGA Yagoub… - Nutrients, 2024 - mdpi.com
Background/Objective: This study examined the anti-obesity effect of royal jelly (RJ) in rats
fed with a high-fat diet by targeting the major pathways involved in adipogenesis and …

Effect of Rab18 on liver injury and lipid accumulation by regulating perilipin 2 and peroxisome proliferator‐activated receptor gamma in non‐alcoholic fatty liver …

L Zhang, L Xu, A Rong, Y Cui, L Wang… - Journal of …, 2024 - Wiley Online Library
Abstract Background and Aim Nonalcoholic fatty liver disease (NAFLD) is currently one of
the most common chronic liver diseases worldwide, characterized by the presence of lipid …

Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review

Y Liu, L Dan, J Tang, Z Yin, L Yang, D Zhang… - Medicinal Chemistry …, 2024 - Springer
Salidroside (Sal), a natural phenolic glycoside ubiquitous across all species of the Rhodiola
genus, has garnered considerable attention in contemporary pharmacological research. Its …