Psychedelics and other psychoplastogens for treating mental illness

MV Vargas, R Meyer, AA Avanes, M Rus… - Frontiers in …, 2021 - frontiersin.org
Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents

RM Brown, MH James - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Overeating ranges in severity from casual overindulgence to an overwhelming drive to
consume certain foods. At its most extreme, overeating can manifest as clinical diagnoses …

The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice

M Favier, E Martin Garcia, R Icick, C de Almeida… - Nature …, 2024 - nature.com
Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3
(VGLUT3) which allows them to regulate the striatal network with glutamate and …

Gut microbiota signatures of vulnerability to food addiction in mice and humans

S Samulėnaitė, A García-Blanco, J Mayneris-Perxachs… - Gut, 2024 - gut.bmj.com
Objective Food addiction is a multifactorial disorder characterised by a loss of control over
food intake that may promote obesity and alter gut microbiota composition. We have …

The nucleus accumbens in reward and aversion processing: insights and implications

Y Xu, Y Lin, M Yu, K Zhou - Frontiers in Behavioral Neuroscience, 2024 - frontiersin.org
The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been
implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily …

Suppression of corticostriatal circuit activity improves cognitive flexibility and prevents body weight loss in activity-based anorexia in rats

LK Milton, PN Mirabella, E Greaves, DC Spanswick… - Biological …, 2021 - Elsevier
Background The ability to adapt behavior to changing environmental circumstances, or
cognitive flexibility, is impaired in multiple psychiatric conditions, including anorexia nervosa …

New directions in modelling dysregulated reward seeking for food and drugs

RM Brown, CV Dayas, MH James, RJ Smith - … & Biobehavioral Reviews, 2022 - Elsevier
Behavioral models are central to behavioral neuroscience. To study the neural mechanisms
of maladaptive behaviors (including binge eating and drug addiction), it is essential to …

Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle

A Rakha, F Mehak, MA Shabbir, M Arslan… - Frontiers in …, 2022 - frontiersin.org
Food intake and body weight regulation are of special interest for meeting today's lifestyle
essential requirements. Since balanced energy intake and expenditure are crucial for …

Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits

R Haddad-Tóvolli, S Ramírez, E Muñoz-Moreno… - Nature …, 2022 - nature.com
Preparation for motherhood requires a myriad of physiological and behavioural adjustments
throughout gestation to provide an adequate environment for proper embryonic …

Binge-Eating Precursors in Children and Adolescents: Neurodevelopment, and the Potential Contribution of Ultra-Processed Foods

E Via, O Contreras-Rodríguez - Nutrients, 2023 - mdpi.com
Binge-eating disorder (BED) is a highly prevalent disorder. Subthreshold BED conditions
(sBED) are even more frequent in youth, but their significance regarding BED etiology and …