Neurodegenerative diseases are the most common causes of disability worldwide. Given
their high prevalence, devastating symptoms, and lack of definitive diagnostic tests, there is …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

The main aims in the care of individuals with amyotrophic lateral sclerosis (ALS) are to
minimize morbidity and maximize quality of life. Although no cure exists for ALS, supportive …

Background A long non-coding RNA (lncRNA), nuclear-enriched abundant transcript 1_2
(NEAT1_2), constitutes nuclear bodies known as “paraspeckles”. Mutations of RNA binding …

Most health-care professionals are trained to promote and maintain life and often have
difficulty when faced with the often rapid decline and death of people with terminal illnesses …

Prospective population based-registers of amyotrophic lateral sclerosis (ALS) have operated
in Europe for over two decades, and have provided important insights into our …

Background Respiratory failure is a significant concern in neuromuscular diseases (NMDs).
This CHEST guideline examines the literature on the respiratory management of patients …

Objectives To describe the natural history and clinical features of sporadic amyotrophic
lateral sclerosis (ALS) in Chinese patients, and to report data on the prognostic factors for …

Background Respiratory failure is associated with significant morbidity and is the
predominant cause of death in motor neurone disease/amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading
to generalized muscle weakness and premature death. Sleep disturbances are extremely …