Building digital twins of the human immune system: toward a roadmap
Digital twins, customized simulation models pioneered in industry, are beginning to be
deployed in medicine and healthcare, with some major successes, for instance in …
deployed in medicine and healthcare, with some major successes, for instance in …
Strategies for efficient numerical implementation of hybrid multi-scale agent-based models to describe biological systems
Biologically related processes operate across multiple spatiotemporal scales. For
computational modeling methodologies to mimic this biological complexity, individual scale …
computational modeling methodologies to mimic this biological complexity, individual scale …
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer
Quantitative systems pharmacology (QSP) modeling is an emerging mechanistic
computational approach that couples drug pharmacokinetics/pharmacodynamics and the …
computational approach that couples drug pharmacokinetics/pharmacodynamics and the …
A QSP model for predicting clinical responses to monotherapy, combination and sequential therapy following CTLA-4, PD-1, and PD-L1 checkpoint blockade
Over the past decade, several immunotherapies have been approved for the treatment of
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
Rapid advances in immunotherapy to treat cancer
JS McCune - Clinical Pharmacology & Therapeutics, 2018 - Wiley Online Library
Immunotherapy is now the fourth pillar of cancer therapy, with surgery, radiation, and
traditional chemotherapy being the remaining pillars. Over the past decade, enthusiasm for …
traditional chemotherapy being the remaining pillars. Over the past decade, enthusiasm for …
[图书][B] Mathematical immunology of virus infections
Understanding the cellular and molecular mechanisms that control the ability of the immune
system to mount a protective response against pathogen-derived foreign antigens, but avoid …
system to mount a protective response against pathogen-derived foreign antigens, but avoid …
[HTML][HTML] The promises of quantitative systems pharmacology modelling for drug development
VR Knight-Schrijver, V Chelliah… - Computational and …, 2016 - Elsevier
Recent growth in annual new therapeutic entity (NTE) approvals by the US Food and Drug
Administration (FDA) suggests a positive trend in current research and development (R&D) …
Administration (FDA) suggests a positive trend in current research and development (R&D) …
QSP‐IO: a quantitative systems pharmacology toolbox for mechanistic multiscale modeling for immuno‐oncology applications
Immunotherapy has shown great potential in the treatment of cancer; however, only a
fraction of patients respond to treatment, and many experience autoimmune‐related side …
fraction of patients respond to treatment, and many experience autoimmune‐related side …
Biomarker‐guided individualization of antibiotic therapy
Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a
major clinical challenge, and is expected to become even more urgent with the global rise of …
major clinical challenge, and is expected to become even more urgent with the global rise of …