Cerebral microbleeds (CMBs) are defined as hypointense foci visible on T2*-weighted and
susceptible-weighted MRI sequences. CMBs are increasingly recognised with the …

Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the …

Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus,
which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature …

White matter hyperintensities (WMH) are among the most common radiological
abnormalities in the ageing population and an established risk factor for stroke and …

Genetic leukoencephalopathies (gLEs) are a highly heterogeneous group of rare genetic
disorders. The spectrum of gLEs varies among patients of different ages. Distinct from the …

Cerebral microvascular disease (MVD) is an important cause of vascular cognitive
impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the …

Cerebral small vessel diseases represent a frequent cause of stroke and cognitive or motor
disability in adults. A small proportion of cerebral small vessel diseases is attributable to …

Strokes are the main cause of death and long-term disability worldwide. A stroke is a
heterogeneous multi-factorial condition, caused by a combination of environmental and …

Heterozygous missense HTRA1 mutations have been associated with an autosomal
dominant cerebral small vessel disease (CSVD) whereas the pathogenicity of heterozygous …

Despite comprehensive research efforts over the last decades, the pathomechanisms of age-
related macular degeneration (AMD) remain far from being understood. Large-scale …