SUMMARY A critical feature of the hypothesized RNA world would have been the ability to
control chemical processes in response to environmental cues. Riboswitches present …

Riboswitches are gene control elements that directly bind to specific ligands to regulate
gene expression without the need for proteins. They are found in all three domains of life …

Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-
binding elements called riboswitches. Although they both bind adenine, the adenine …

Abstract The cyclic diguanylate (bis-(3′-5′)-cyclic dimeric guanosine monophosphate, c-
di-GMP) riboswitch is the first known example of a gene-regulatory RNA that binds a second …

Introduction The growth of antibiotic resistance among bacterial pathogens is an impending
global threat that can only be averted through the development of novel antibacterial drugs …

Riboswitches are mRNA elements capable of modulating gene expression in response to
specific binding by cellular metabolites. Riboswitches exert their function through the …

Riboswitches are regulatory elements modulating gene expression in response to specific
metabolite binding. It has been recently reported that riboswitch agonists may exhibit …

Riboswitches are metabolite-sensitive elements found in mRNAs that control gene
expression through a regulatory secondary structural switch. Along with regulation of lysine …

RNA-based biosensors and regulatory devices have received significant attention for their
potential in a broad array of synthetic biology applications. One of the primary difficulties in …

Therapeutic approaches employing RNA as a tool or as a drug target have recently
emerged and have been employed for various applications—ranging from cancer treatment …