Neuronal development is a highly regulated mechanism that is central to organismal
function in animals. In humans, disruptions to this process can lead to a range of …

The study of diseases of the central nervous system (CNS) at the molecular level is
challenging because of the complexity of neural circuits and the huge number of specialized …

The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …

Genetic studies of schizophrenia (SCZ) reveal a complex polygenic risk architecture
comprised of hundreds of risk variants, the majority of which are common in the population …

There is an urgent and unmet need to advance our ability to translate genetic studies of
psychiatric disorders into clinically actionable information, which could transform diagnostics …

Feeding and eating disorders (FEDs) are heterogenous and characterized by varying
patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are …

Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and
CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human …

Common variants associated with schizophrenia are concentrated in non-coding regulatory
sequences, but their precise target genes are context-dependent and impacted by cell-type …

Over a hundred risk genes underlie risk for autism spectrum disorder (ASD) but the extent to
which they converge on shared downstream targets to increase ASD risk is unknown. To test …