Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease
(AD), extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological …

Extracellular vesicles (EVs) are important means of intercellular communication and a potent
tool for regenerative therapy. In ischaemic stroke, transient blockage of a brain artery leads …

Highlights•Protein lipidation is an essential modification (PTM) in all forms of life.•Key
modifications include acylation, prenylation, cholesterylation and GPI anchors.•Global …

Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein
(PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative …

The study of prions as infectious aggregates dates several decades. From its original
formulation, the definition of a prion has progressively changed to the point that many …

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by
a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible …

Cellular prion protein (PrP C) modulates cell adhesion and signaling in the brain.
Conversion to its infectious isoform causes neurodegeneration, including Creutzfeldt-Jakob …

Endoplasmic reticulum (ER) quality control mechanisms target terminally misfolded proteins
for ER-associated degradation (ERAD). Misfolded glycophosphatidylinositol-anchored …