Alcohol is a psychoactive substance that is widely used and, unfortunately, often abused. In
addition to acute effects such as intoxication, it may cause many chronic pathological …

Acylation modifications play a central role in biological and physiological processes. Across
a range of biomolecules from phospholipids to triglycerides to proteins, introduction of a …

Existing literature indicates that communication between the central nervous system and the
peripheral nervous system is disrupted by substance use disorders (SUDs), including …

According to data from the World Health Organization, there were about 3 million deaths
caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver …

Cocaine addiction is a significant medical and public concern. Despite decades of research
effort, development of pharmacotherapy for cocaine use disorder remains largely …

The acylated peptide hormone ghrelin impacts a wide range of physiological processes but
is most well known for controlling hunger and metabolic regulation. Ghrelin requires a …

Ghrelin is a stomach-derived peptide hormone that acts via the growth hormone
secretagogue receptor (GHSR) and displays a plethora of neuroendocrine, metabolic …

The circuitry of addiction comprises several neural networks including the midbrain-an
expansive region critically involved in the control of motivated behaviors. Midbrain nuclei …

Preclinical and human studies suggest a role of aldosterone and mineralocorticoid receptor
(MR) in addiction. This scoping review aimed to summarize (1) the relationship between …

Purpose: Over the past 40–50 years, demographic shifts and the obesity epidemic have
coincided with significant changes in lifestyle habits, including a rise in excessive alcohol …