[HTML][HTML] Bile acids and FXR: novel targets for liver diseases
M Stofan, GL Guo - Frontiers in medicine, 2020 - frontiersin.org
Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …
[HTML][HTML] Bile acids and their receptors: modulators and therapeutic targets in liver inflammation
A Bertolini, R Fiorotto, M Strazzabosco - Seminars in immunopathology, 2022 - Springer
Bile acids participate in the intestinal emulsion, digestion, and absorption of lipids and fat-
soluble vitamins. When present in high concentrations, as in cholestatic liver diseases, bile …
soluble vitamins. When present in high concentrations, as in cholestatic liver diseases, bile …
[HTML][HTML] Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice
A Zhuge, S Li, Y Yuan, S Han, J Xia, Q Wang, S Wang… - Redox Biology, 2023 - Elsevier
Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH),
but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III …
but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III …
[HTML][HTML] Farnesoid X receptor as target for therapies to treat cholestasis-induced liver injury
AD Petrescu, S DeMorrow - Cells, 2021 - mdpi.com
Recent studies on liver disease burden worldwide estimated that cirrhosis is the 11th most
common cause of death globally, and there is a great need for new therapies to limit the …
common cause of death globally, and there is a great need for new therapies to limit the …
Predictors of serious adverse events and non‐response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid
A De Vincentis, D D'Amato, L Cristoferi… - Liver …, 2022 - Wiley Online Library
Abstract Background & Aims Obeticholic acid (OCA) has recently been restricted in patients
with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow …
with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow …
Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway
T Zhang, S Feng, J Li, Z Wu, Q Deng, W Yang, J Li… - Archives of …, 2022 - Springer
Farnesoid X receptor (FXR) plays an indispensable role in liver homeostasis and has been
a promising drug target for hepatic diseases. However, the concerns of undesired biological …
a promising drug target for hepatic diseases. However, the concerns of undesired biological …
Molecular pathways governing the termination of liver regeneration
LR de Haan, RF van Golen, M Heger - Pharmacological reviews, 2024 - ASPET
The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed
without detrimental consequences to the organism. Liver regeneration is a complex process …
without detrimental consequences to the organism. Liver regeneration is a complex process …
[HTML][HTML] Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats
R Wang, T Yuan, J Sun, M Yang, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Cholestasis, characterized by disturbance of bile formation, is a common pathological
condition that can induce several serious liver diseases. As a kind of trigger, estrogen …
condition that can induce several serious liver diseases. As a kind of trigger, estrogen …
[HTML][HTML] Recent evaluation about inflammatory mechanisms in nonalcoholic fatty liver disease
C Song, X Long, J He, Y Huang - Frontiers in Pharmacology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is common chronic metabolic liver disorder which
is associated with fat accumulation in the liver. It causes a wide range of pathological effects …
is associated with fat accumulation in the liver. It causes a wide range of pathological effects …
[PDF][PDF] 核受体FXR 在肝星状细胞及肝纤维化中的作用
蒲诗云， 任常谕 - 生理科学进展, 2022 - physiol.bjmu.edu.cn
摘要法尼醇X 受体(farnesoidXreceptor, FXR) 是核受体超家族的重要成员, 以作为胆汁酸受体被
大家所熟知. 除了调节胆汁酸的合成和转运, FXR 在调控葡萄糖代谢, 甘油三酯代谢, 炎症 …
大家所熟知. 除了调节胆汁酸的合成和转运, FXR 在调控葡萄糖代谢, 甘油三酯代谢, 炎症 …