The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
MA Atkinson, RG Mirmira - Cell Metabolism, 2023 - cell.com
Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer
PA Hart, MD Bellin, DK Andersen, D Bradley… - The lancet …, 2016 - thelancet.com
Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2
diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and …
diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and …
Diabetes, pancreatogenic diabetes, and pancreatic cancer
The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are
complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but …
complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but …
Targeted elimination of senescent beta cells prevents type 1 diabetes
Summary Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by
hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell …
hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell …
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
CC Robertson, JRJ Inshaw, S Onengut-Gumuscu… - Nature …, 2021 - nature.com
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …
[HTML][HTML] Stress-induced β cell early senescence confers protection against type 1 diabetes
During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …
Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach
The rising prevalence of childhood obesity has been postulated as an explanation for the
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …
Unconventional neurotrophic factors CDNF and MANF: structure, physiological functions and therapeutic potential
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived
neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which …
neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which …
Beta cell dedifferentiation induced by IRE1α deletion prevents type 1 diabetes
H Lee, YS Lee, Q Harenda, S Pietrzak, HZ Oktay… - Cell metabolism, 2020 - cell.com
Immune-mediated destruction of insulin-producing β cells causes type 1 diabetes (T1D).
However, how β cells participate in their own destruction during the disease process is …
However, how β cells participate in their own destruction during the disease process is …
Type 1 diabetes: a chronic anti-self-inflammatory response
M Clark, CJ Kroger, RM Tisch - Frontiers in immunology, 2017 - frontiersin.org
Inflammation is typically induced in response to a microbial infection. The release of
proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as …
proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as …